{"id":12363,"date":"2025-03-12T19:51:52","date_gmt":"2025-03-12T23:51:52","guid":{"rendered":"https:\/\/dondevacunarsepr.com\/?p=12363"},"modified":"2025-03-12T19:51:52","modified_gmt":"2025-03-12T23:51:52","slug":"vacuna-de-arnm-muestra-avances-en-el-tratamiento-del-cancer-de-pancreas","status":"publish","type":"post","link":"https:\/\/dondevacunarsepr.com\/vacuna-de-arnm-muestra-avances-en-el-tratamiento-del-cancer-de-pancreas\/","title":{"rendered":"Vacuna de ARNm muestra avances en el tratamiento del c\u00e1ncer de p\u00e1ncreas"},"content":{"rendered":"<p data-pm-slice=\"1 1 []\">Un estudio pionero del <a href=\"https:\/\/www.mskcc.org\/es\/cancer-care\" target=\"_blank\" rel=\"noopener\">Centro Oncol\u00f3gico Memorial Sloan Kettering<\/a> ha demostrado el potencial de una vacuna de ARNm personalizada como complemento al tratamiento est\u00e1ndar del<a href=\"https:\/\/dondevacunarsepr.com\/expertos-respaldan-la-vacunacion-en-ninos-con-cancer-en-latinoamerica\/\" target=\"_blank\" rel=\"noopener\"> c\u00e1ncer de p\u00e1ncreas<\/a>. Este enfoque innovador tiene como objetivo activar el sistema inmunol\u00f3gico del paciente para identificar y<strong> combatir las <a href=\"https:\/\/dondevacunarsepr.com\/de-la-pandemia-al-cancer-la-revolucion-del-arn-mensajero-en-oncologia\/\" target=\"_blank\" rel=\"noopener\">c\u00e9lulas cancerosas<\/a>, un reto clave en la lucha contra esta enfermedad altamente letal.<\/strong><\/p>\n<p>El c\u00e1ncer de p\u00e1ncreas es una de las formas m\u00e1s agresivas de la enfermedad, con una tasa de supervivencia extremadamente <strong>baja debido a su detecci\u00f3n tard\u00eda y la resistencia a los tratamientos convencionales. En este estudio<\/strong>, 16 pacientes diagnosticados en etapa temprana, incluyendo a Barbara Brigham, participaron en un ensayo cl\u00ednico en el que, adem\u00e1s de someterse a cirug\u00eda y quimioterapia, recibieron una vacuna de ARNm personalizada basada en las mutaciones gen\u00e9ticas de sus propios tumores.<\/p>\n<pre>Lea:\u00a0<a href=\"https:\/\/dondevacunarsepr.com\/expertos-respaldan-la-vacunacion-en-ninos-con-cancer-en-latinoamerica\/\" target=\"_blank\" rel=\"noopener\">Expertos respaldan la vacunaci\u00f3n en ni\u00f1os con c\u00e1ncer en Latinoam\u00e9rica<\/a><\/pre>\n<blockquote><p>Esta estrategia difiere de las vacunas convencionales, que previenen enfermedades, ya que su prop\u00f3sito es instruir al sistema inmunol\u00f3gico del paciente para que reconozca y ataque c\u00e9lulas malignas espec\u00edficas.<\/p><\/blockquote>\n<h3>Resultados alentadores y retos en la investigaci\u00f3n<\/h3>\n<p>Los hallazgos publicados en la <a href=\"https:\/\/www.nature.com\/\" target=\"_blank\" rel=\"noopener\">revista Nature<\/a> revelaron que ocho de los 16 pacientes mostraron una respuesta inmunitaria robusta. De estos, seis permanecieron libres de c\u00e1ncer despu\u00e9s de tres a\u00f1os de seguimiento. <strong>En contraste, siete de los ocho pacientes que no desarrollaron una respuesta inmunitaria efectiva experimentaron recurrencias tumorales.<\/strong> Una observaci\u00f3n clave fue la relaci\u00f3n entre la efectividad de la vacuna y la conservaci\u00f3n del bazo, un \u00f3rgano que desempe\u00f1a un papel crucial en la respuesta inmunol\u00f3gica del cuerpo.<\/p>\n<blockquote><p>El doctor Vinod Balachandran, cirujano onc\u00f3logo especializado en c\u00e1ncer de p\u00e1ncreas y l\u00edder del estudio, destac\u00f3 que aunque los resultados son prometedores, el tama\u00f1o reducido de la muestra impide atribuir el \u00e9xito \u00fanicamente a la vacuna.<\/p><\/blockquote>\n<p>Actualmente, se est\u00e1 llevando a cabo un ensayo cl\u00ednico aleatorizado con una cohorte m\u00e1s amplia de pacientes en etapa temprana cuyo bazo no haya sido removido. Los investigadores esperan obtener datos m\u00e1s concluyentes sobre la eficacia y seguridad de esta estrategia<a href=\"https:\/\/dondevacunarsepr.com\/el-abc-de-las-vacunas-que-son-como-funcionan-y-por-que-son-importantes\/\" target=\"_blank\" rel=\"noopener\"> inmunoterap\u00e9utica<\/a>.<\/p>\n<pre>M\u00e1s:\u00a0<a href=\"https:\/\/dondevacunarsepr.com\/puede-el-sarampion-volver-a-puerto-rico-autoridades-instan-a-la-vacunacion\/\" target=\"_blank\" rel=\"noopener\">\u00bfPuede el sarampi\u00f3n volver a Puerto Rico? Autoridades instan a la vacunaci\u00f3n<\/a><\/pre>\n<p>Adem\u00e1s del c\u00e1ncer de p\u00e1ncreas, se est\u00e1n desarrollando vacunas de ARNm dirigidas a otros tipos de tumores, como melanoma y c\u00e1nceres de pulm\u00f3n y ri\u00f1\u00f3n, que presentan tasas de mutaci\u00f3n m\u00e1s elevadas y podr\u00edan responder de manera m\u00e1s efectiva a este tipo de inmunoterapia.<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_12363\" class=\"pvc_stats all  \" data-element-id=\"12363\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.0\" viewBox=\"0 0 502 315\" preserveAspectRatio=\"xMidYMid meet\"><g transform=\"translate(0,332) scale(0.1,-0.1)\" fill=\"\" stroke=\"none\"><path d=\"M2394 3279 l-29 -30 -3 -207 c-2 -182 0 -211 15 -242 39 -76 157 -76 196 0 15 31 17 60 15 243 l-3 209 -33 29 c-26 23 -41 29 -80 29 -41 0 -53 -5 -78 -31z\"\/><path d=\"M3085 3251 c-45 -19 -58 -50 -96 -229 -47 -217 -49 -260 -13 -295 52 -53 146 -42 177 20 16 31 87 366 87 410 0 70 -86 122 -155 94z\"\/><path d=\"M1751 3234 c-13 -9 -29 -31 -37 -50 -12 -29 -10 -49 21 -204 19 -94 39 -189 45 -210 14 -50 54 -80 110 -80 34 0 48 6 76 34 21 21 34 44 34 59 0 14 -18 113 -40 219 -37 178 -43 195 -70 221 -36 32 -101 37 -139 11z\"\/><path d=\"M1163 3073 c-36 -7 -73 -59 -73 -102 0 -56 133 -378 171 -413 34 -32 83 -37 129 -13 70 36 67 87 -16 290 -86 209 -89 214 -129 231 -35 14 -42 15 -82 7z\"\/><path d=\"M3689 3066 c-15 -9 -33 -30 -42 -48 -48 -103 -147 -355 -147 -375 0 -98 131 -148 192 -74 13 15 57 108 97 206 80 196 84 226 37 273 -30 30 -99 39 -137 18z\"\/><path d=\"M583 2784 c-38 -19 -67 -74 -58 -113 9 -42 211 -354 242 -373 16 -10 45 -18 66 -18 51 0 107 52 107 100 0 39 -1 41 -124 234 -80 126 -108 162 -133 173 -41 17 -61 16 -100 -3z\"\/><path d=\"M4250 2784 c-14 -9 -74 -91 -133 -183 -95 -150 -107 -173 -107 -213 0 -55 33 -94 87 -104 67 -13 90 8 211 198 130 202 137 225 78 284 -27 27 -42 34 -72 34 -22 0 -50 -8 -64 -16z\"\/><path d=\"M2275 2693 c-553 -48 -1095 -270 -1585 -649 -135 -104 -459 -423 -483 -476 -23 -49 -22 -139 2 -186 73 -142 361 -457 571 -626 285 -228 642 -407 990 -497 242 -63 336 -73 660 -74 310 0 370 5 595 52 535 111 1045 392 1455 803 122 121 250 273 275 326 19 41 19 137 0 174 -41 79 -309 363 -465 492 -447 370 -946 591 -1479 653 -113 14 -422 18 -536 8z m395 -428 c171 -34 330 -124 456 -258 112 -119 167 -219 211 -378 27 -96 24 -300 -5 -401 -72 -255 -236 -447 -474 -557 -132 -62 -201 -76 -368 -76 -167 0 -236 14 -368 76 -213 98 -373 271 -451 485 -162 444 86 934 547 1084 153 49 292 57 452 25z m909 -232 c222 -123 408 -262 593 -441 76 -74 138 -139 138 -144 0 -16 -233 -242 -330 -319 -155 -123 -309 -223 -461 -299 l-81 -41 32 46 c18 26 49 83 70 128 143 306 141 649 -6 957 -25 52 -61 116 -79 142 l-34 47 45 -20 c26 -10 76 -36 113 -56z m-2057 25 c-40 -58 -105 -190 -130 -263 -110 -324 -59 -707 132 -981 25 -35 42 -64 37 -64 -19 0 -241 119 -326 174 -188 122 -406 314 -532 468 l-58 71 108 103 c185 178 428 349 672 473 66 33 121 60 123 61 2 0 -10 -19 -26 -42z\"\/><path d=\"M2375 1950 c-198 -44 -350 -190 -395 -379 -18 -76 -8 -221 19 -290 114 -284 457 -406 731 -260 98 52 188 154 231 260 27 69 37 214 19 290 -38 163 -166 304 -326 360 -67 23 -215 33 -279 19z\"\/><\/g><\/svg><\/i> <img decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"https:\/\/dondevacunarsepr.com\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudio pionero del Centro Oncol\u00f3gico Memorial Sloan Kettering ha demostrado el potencial de una vacuna de ARNm personalizada como complemento al tratamiento est\u00e1ndar del c\u00e1ncer de p\u00e1ncreas. Este enfoque innovador tiene como objetivo activar el sistema inmunol\u00f3gico del paciente para identificar y combatir las c\u00e9lulas cancerosas, un reto clave en la lucha contra esta [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":12364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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